Succinate: a serum biomarker of SDHB mutated paragangliomas and pheochromocytomas.

Constance Lamy, Hubert Tissot,Matthieu Faron,Eric Baudin,Livia Lamartina,Caroline Pradon,Abir Al Ghuzlan,Sophie Leboulleux,Jean-Luc Perfettini,Angelo Paci,Julien Hadoux,Sophie Broutin

The Journal of clinical endocrinology and metabolism（2022）

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摘要

In this pilot study, we showed that serum succinate level is an oncometabolic biomarker that should be useful to identify SDHB-related carriers. Succinate levels are also a marker of metabolic tumor burden in patients with a metastatic PPGL and a potential marker of treatment response and follow-up.

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关键词

SDH,biomarker,paraganglioma,pheochromocytoma,succinate

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