Micro-arc oxidation preparation of a ZnO-Se composite coating on titanium with anti-oxidation and anti-bacterial potentials for osteomyelitis control

Osteomyelitis is a severe bone infection with a high rate of relapse. Given the fact that occurrence/relapse of osteomyelitis is associated with the presence of foreign bodies, it is highly desired to develop orthopedic implant with long-term anti-infection and anti-inflammation properties. In current work, zinc oxide-selenium (ZnO-Se) composite coatings were fabricated on titanium surface via micro-arc oxidation (MAO) processing purposed to generate integrated functional surface for osteomyelitis control. On one hand, the combination of ZnO and Se could inhibit the adherence of S. aureus, which accounts for majority of osteomyelitis occurrence. On the other hand, the anti-oxidation significance of Se was purposed to reduce inflammation severity. The subsequent material characterizations, DPPH radicals scavenge test, cell culture and anti-bacterial test confirmed the potential of ZnO-Se MAO coating in osteomyelitis control, thereby providing a facile option for titanium implant surface modification.