Structure-activity relationship studies on divalent naphthalene diimide G quadruplex ligands with anticancer and antiparasitic activity
Bioorganic & Medicinal Chemistry(2022)
Abstract
•Synthesis of new G-quadruplex ligands based on naphthalene diimide (NDI).•Structure activity relationships keeping NDI and modifying spacer and cationic groups.•Testing the in vitro anticancer and antiparasitic activity.•N-methylpiperazine NDIs with flexible linkers were the best G4 ligands.•Found a dimorpholine NDI as the best candidate against T.brucei.
MoreTranslated text
Key words
G-quadruplex,Ligand,Naphthalene diimide,Antiproliferative,Antiparasitic
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined