Base-Promoted Regioselective Bromination of imidazo[1,2-alpha]pyridines with CBr4 as Bromine Source

Pei He,Chunbo Liu,Qinpeng Shen,Jianjun Xia,Ying Han,Wen Xiong,Zhenjie Li,Shiyun Tang,Zhihua Liu,Fengmei Zhang

Letters in Organic Chemistry（2023）

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Abstract

A bromination of hydrocarbons with CBr4 as a bromine source, promoted by NaOH, has been developed. The reaction method with high efficiency and regioselectivity for the synthesis of C3-brominated imidazo[1,2-alpha]pyridines. An effective and simple method of C-X bond construction has been developed, which is a supplement to the halide of imidazo[1,2-alpha]pyridines.

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Key words

Base-promoted,bromination,C-Br bond forming,imidazo[1,2-alpha]pyridines,hydrocarbons,halide

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