Exercise timing influences multi-tissue metabolome and skeletal muscle proteome profiles in type 2 diabetic patients – A randomized crossover trial

•Several distinct responses are apparent between high intensity interval training (HIT) performed in the morning and afternoon•Morning training raised plasma carbohydrates and skeletal muscle lipoproteins more robustly than afternoon HIT•Afternoon HIT increased skeletal muscle lipids and mitochondrial complex III abundance to a greater extent than morning HIT•Exercise timing may be important to consider for the management of type 2 diabetes