Accelerating SLC Transporter Research: Streamlining Knowledge and Validated Tools

A modern, rational approach to a large class of proteins broadly relevant for pharmacology is enabling both from a postgenomic perspective and for reasons of economy of scale. The international public-private consortia RESOLUTE (https://re-solute.eu/) and REsolution (https://re-solute.eu/resolution) are generating a systematic functional assignment of each of the 451 different human solute carrier (SLC) proteins and, at the same time, trying to catalog and interpret the associated main genetic variants.