Reduced phagocytic activity of human alveolar macrophages infected with Mycobacterium avium complex

Hiroaki Ikegami,Kei Yamasaki,Midori Ogawa,Kazuki Nemoto,Kentaro Akata,Shingo Noguchi,Kazumasa Fukuda,Toshinori Kawanami,Hiroshi Mukae,Kazuhiro Yatera

Journal of Infection and Chemotherapy（2022）

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摘要

The proportion of alveolar macrophages (HLA-DR, CD40, and CD163) with impaired phagocytosis increased in MAC-infected individuals. M. intracellulare-infected macrophages reduced bactericidal activity in vitro. Dysfunction of alveolar macrophages may contribute to persistent infection by other bacteria, leading to MAC lung disease progression.

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关键词

Macrophage,Mycobacterium avium complex,Nontuberculous mycobacterial lung disease

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