The Expression and Clinical Significance of IL-4 and IL-13 in Papillary Thyroid Carcinoma

Papillary thyroid carcinoma (PTC) is one of the most common thyroid tumors in clinic. The incidence of papillary thyroid carcinoma is increasing year by year, especially in Cangzhou area, which brings great physical and mental pain to patients. Object: To explore the expression and clinical significance of interleukin-4 (IL-4) and interleukin-13 (IL-13) in the tissues and serum of patients with papillary thyroid carcinoma (PTC). Method: 120 cases of PTC patients were randomly selected as the experimental group, who underwent radical mastectomy at the Thyroid and Breast Surgery Department of Cangzhou Central Hospital from January 2018 to April 2019, and the PTC tissues and their adjacent tissues and serum samples were collected. 120 healthy people were matched 1:1 as the control group in the hospital physical examination center during the same period, according to the gender, age and body mass index of the experimental group, and serum samples were collected. The immunohisto chemical SP method is adopted to test the expression of IL-4 and IL-13 in the tissues, and the ELISA is adopted to test the serum levels of IL-4 and IL-13. Analyze the relationship between IL-4 and IL-13 expression and clinicopathological characteristics in PTC. Result: It was significantly higher with the positive expression rate of IL-4 and IL-13 in PTC tissues than that in adjacent tissues (P<0.05), and it was a significant positive correlation between IL-4 and IL-13 expressed in PTC tissues (r=0.375, P=0.002); It was significantly higher in the serum levels of IL-4 and IL-13 in PTC patients, than that in healthy subjects (P<0.05), and it was a significant positive correlation between IL-4 and IL-13 expressed in the serum of PTC patients (r=0.381, P<0.01); The expression of IL-4 and IL-13 was related to the maximum tumor diameter, TNM stage, degree of differentiation, and lymphatic metastasis in PTC (P<0.05). Conclusion: IL-4 and IL-13 were highly expressed in PTC, and the expression level may become a reference indicator for predicting the occurrence and development of PTC.