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mTORC1 is required for epigenetic silencing during β-cell functional maturation

Qicheng Ni,Jiajun Sun,Yichen Wang,Yanqiu Wang,Jingwen Liu,Guang Ning,Weiqing Wang,Qidi Wang

Molecular Metabolism（2022）

Cited 6|Views9
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Abstract
•Rescued DNMT3A expression in Raptor-deficient islets partially reversed the abnormal induction of immature genes.•EED/H3K27me3 were impaired in Raptor-ablated β-cell.•DNA methylation and H3K27me3 are required for mTORC1-dependent epigenetic silencing of immature genes in β-cell.
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Key words
β-Cell,Type 2 diabetes,mTORC1,Epigenetic regulation,Dnmt3a,H3K27me3
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