Non-infectious Complications in Patients with Allogeneic Hematopoietic Stem Cell Transplantation- Single Center Experience from Eastern Anatolia

Introduction:The aim of this study was to investigate late non-infectious complications in patients with allogeneic hematopoietic stem cell transplantation (HSCT). Materials and Methods:The records of 143 patients who underwent allogeneic HSCT between 01.02.2011 and 31.12.2018 in Inonu University Turgut Özal Medical Center Department of Hematology were retrospectively reviewed.Results: In our study, late non-infectious complications were seen in 68 % of the patients.Graft Versus Host Disease (GVHD) was observed in 43 patients (33%) %.The most common GVHD involvement sites were skin and liver.It was determined that the number of CD 34 (+) cells had a significant effect on the development of chronic GVHD (p=0,01) and late stage complications (p=0,016).Chronic GVHD and late complication rates were found to be lower in the group given high CD 34 (+) cell count.When the patients were grouped according to the preparation regimens, statistically significantly more complications were observed at the rate of 78.8% in the patients in the myeloablative regimen group (p=0.005).It was observed that the rate of recurrence of the primary disease, renal complications and neurological complications was higher in the 90-120th days after transplantation.Ocular and GVHD complications were more likely to develop later.It was observed that endocrine complications were encountered equally in both early and late periods.Discussion: It was seen that, late complications were common in patients who underwent allogeneic HSCT and these complications were mostly related to GVHD and GVHD treatment.