Evaluation of Cancer Cell Growth Suppressibility of omega-3 Fatty Acids and Their Metabolites

According to current research, cancer cell growth is suppressed by omega-3 fatty acids, which are essential fatty acids. On the other hand, omega-3 fatty acids are metabolized to bioactivities in vivo. A systematic evaluation of the ability of omega-3 fatty acids and their metabolites to suppress cancer cell growth has not been sufficiently conducted. Our work evaluated the effect of omega-3 fatty acids (docosahexaenoic acid, eicosapentaenoic acid), trans fatty acid, and the metabolites (Resolvin E1, Maresin 1) on cancer cell growth suppressibility. Our results suggest that there may be optimal fatty acids depending on the kind of cancer cells, the presence or absence of hydroxyl group, and the double bond structure involved.