Discovery of potential active ingredients of Er-Zhi-Wan, a famous traditional Chinese formulation, in model rat serum for treating osteoporosis with kidney-yin deficiency by UPLC-Q/TOF-MS and molecular docking

Mengting Gao,Xin Xue,Xuemeng Zhang,Yueyue Chang,Qiulan Zhang,Xin Li,Yifei Wang,Li Zhang,Zhipeng Li,Haijuan Dong,Wei Wang,Weifeng Yao

Journal of Chromatography B（2022）

引用 4|浏览19

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摘要

•A comprehensive strategy was established to find potential active ingredients.•The relatively complete metabolic profile of Er-Zhi-Wan (EZW) were firstly proposed.•Constituents of EZW absorbed into blood in model rats were different from normal.•Molecular docking and in vitro test were used to find potential active ingredients.

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关键词

Chinese herbal medicine,Constituents absorbed into blood,Differential metabolites,Liquid chromatography-mass spectrometry,Potential active ingredients

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