Zinc finger protein 384 ( ZNF384 ) impact on childhood mixed phenotype acute leukemia and B-cell precursor acute lymphoblastic leukemia.

B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is a heterogeneous malignancy and consists of several genetic abnormalities. Some of these abnormalities are used in clinics for risk calculation and treatment decisions. Patients with rearrangements had a distinct expression profile regardless of their diagnosis, BCP-ALL or mixed phenotype acute leukemia (MPAL) and defined as a new subtype of ALL. In this study, we screened 42 MPAL and 91 BCP-ALL patients for the most common fusions; Z and by using PCR. We identified fusions in 9.5% of MPAL and 7.6% of BCP-ALL. A novel breakpoint was identified in fusion in one BCP-ALL patient. T-myeloid MPAL patients showed significantly lower expression compared to lymphoid groups. Patients with r had intermediate survival rates based on other subtypes. Prognostic and patient-specific treatment evaluation of fusions in both ALL and MPAL might help to improve risk characterization of patients.