Targeting the Deubiquitinase USP7 for Degradation with PROTACs.
CHEMICAL COMMUNICATIONS(2022)
Abstract
A novel class of USP7 PROTACs were designed and synthesized. CST967, a CRBN-based degrader, showed potent and selective depletion of USP7 leading to apoptosis in multiple cancer lines.
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Key words
PROTACs,Protein Degradation
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