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Targeting the Deubiquitinase USP7 for Degradation with PROTACs.

Arunima Murgai,Izidor Sosic,Martina Gobec,Patricia Lemnitzer,Matic Proj,Sophie Wittenburg,Rabea Voget,Michael Guetschow,Jan Kroenke,Christian Steinebach

CHEMICAL COMMUNICATIONS（2022）

Cited 9|Views18
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Abstract
A novel class of USP7 PROTACs were designed and synthesized. CST967, a CRBN-based degrader, showed potent and selective depletion of USP7 leading to apoptosis in multiple cancer lines.
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Key words
PROTACs,Protein Degradation
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