Histone deacetylase inhibition by gut microbe-generated short chain fatty acids entrains intestinal epithelial circadian rhythms.

Jibraan A Fawad,Deborah H Luzader, Gabriel F Hanson,Thomas J Moutinho,Craig A McKinney,Paul G Mitchell,Kathleen Brown-Steinke, Ajay Kumar,Miri Park,Suengwon Lee,David T Bolick,Greg L Medlock,Jesse Y Zhao,Andrew E Rosselot,C James Chou,Emily Eshleman,Theresa Alenghat,Christian I Hong,Jason A Papin,Sean R Moore

Gastroenterology（2022）

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摘要

Gut microbe-generated SCFAs entrain intestinal epithelial circadian rhythms by an HDACi-dependent mechanism, with critical implications for understanding microbial and circadian network regulation of intestinal epithelial homeostasis.

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关键词

circadian rhythm,histone deacetylation,intestinal organoids,microbiome,short chain fatty acids

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