Factors associated with seizure severity among children with epilepsy in Northern Nigeria.
Ghana medical journal(2022)
摘要
Objective:To describe how seizure severity in children with epilepsy may be affected by certain socio-demographic and clinical variables.
Design:A cross-sectional study.
Setting:At the Abubakar Tafawa Balewa University Teaching Hospital, Bauchi, Nigeria.
Participants:Sixty children and adolescents who were being followed up for seizure disorder at the child neurology clinic.
Intervention:Information on socio-demographic characteristics was obtained with a questionnaire, details of neurological co-morbidities were extracted from the participants' records, and seizure severity was assessed with the National Hospital Seizure Severity Score 3 tool.
Main Outcome Measure:Chi-square test was used to establish the relationship between categorical variables, while the Independent t-test was used in describing the differences between means. Simple linear regression was calculated to assess the predictability of seizure severity.
Result:The median age was ten years (IQR = 6-13 years), with a male dominance (1.5:1). The Seizure Severity Score (SSS) ranged between 3 and 24 units, with a mean of 12.22 ± 4.29 units. The only characteristic that had a significant association with SSS on bivariate analysis was the "presence of co-morbidities" (p=0.019). A simple linear regression revealed that the presence of a neurological co-morbidity predicted an increase in the SSS by 2.67 units. [R2 = 0.091, F (1, 58)= 5.837, p = 0.019. β = 2.67, t= 2.42, p= 0.019.].
Conclusion:This study shows that neurological co-morbidities predict worsening seizure severity. This knowledge may influence prognostication and the charting of a treatment trajectory.
Funding:No external funding.
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关键词
Children,Co-morbidities,Epilepsy,Predictors,Seizure Severity,Sub-Saharan Africa
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