Selonsertib Enhances Kidney Protection Beyond Standard of Care in a Hypertensive, Secondary Glomerulosclerosis CKD Model.

Shawn S Badal,Tareq Al Tuhaifi, Ya-Fen Yu,David Lopez,Craig T Plato, Kristin Joly,David G Breckenridge,Hai-Chun Yang,John T Liles,Agnes B Fogo

Kidney360（2022）

引用 3|浏览7

暂无评分

摘要

Selonsertib targets a novel, nonhemodynamic pathway in CKD. Our data suggest that ASK1 inhibition, when combined with ACEI, has additive effects to reduce progression of glomerulosclerosis, attenuate kidney function decline, and reduce podocyte loss.

查看译文

关键词

angiotensin-converting enzyme inhibitor,apoptosis signal-regulating kinase 1 inhibitor,basic science,chronic kidney disease,diabetic kidney disease,selonsertib

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要