Determinants of label non-adherence to non-vitamin K oral anticoagulants in patients with newly diagnosed atrial fibrillation.

J Seelig,E M Trinks-Roerdink,G Chu, R Pisters, L J H J Theunissen,S A Trines, L Pos, C J H J Kirchhof,S F A M S de Jong, F R den Hartog, A P van Alem, P E Polak, R G Tieleman,P H van der Voort,T Lenderink, A M Otten,J S S G de Jong, Y L Gu, J G L M Luermans, M J H A Kruip, S A J Timmer,T A C de Vries,H Ten Cate,G J Geersing,F H Rutten, M V Huisman,M E W Hemels

European heart journal open（2022）

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摘要

In newly diagnosed Dutch AF patients, off-label dosing of NOACs was seen in only 6.6% of patients, most often underdosing. In this study, determinants of off-label dosing were age, renal function, weight, anaemia, active malignancy, and concomitant use of antiplatelets.

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关键词

Anticoagulants,Atrial fibrillation,Off-label use,Prospective studies,Registries

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