Fusion transcript analysis reveals slower response kinetics than multiparameter flow cytometry in childhood acute myeloid leukaemia.

Lene Karlsson,Charlotte Guldborg Nyvold,Anastasia Soboli,Pegah Johansson,Lars Palmqvist,Anne Tierens,Henrik Hasle,Birgitte Lausen,Ólafur Gisli Jónsson, Gitte Wulff Jürgensen,Lene Hyldahl Ebbesen,Jonas Abrahamsson,Linda Fogelstrand

International journal of laboratory hematology（2022）

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摘要

Measurement with RT-qPCR suggests slower response kinetics than indicated from MFC, presumably due to the presence of mature cells expressing fusion transcript. The prognostic impact of early measurements with RT-qPCR remains to be determined.

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关键词

RT-qPCR,acute myeloid leukaemia,fusion transcript,measurable residual disease,multiparameter flow cytometry

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