Wettability‐Based Cell Sorting: Exploring Label‐Free Isolation Strategy for Mixed Primary Glial Cell Population (Adv. Mater. Interfaces 22/2022)

Wettability-Based Cell Sorting A wettability-controlled substrate can be used to separate multiple cell types without the need for a complex labeling procedure, as shown in article number 2200388 by Eunyoung Park, Jennifer Shin, and co-workers. Mixed glial brain cells cultured on a hydrophobic substrate spontaneously segregate into substrate-adherent microglia (green-yellow) and spheroidal aggregates of astrocyte/oligodendrocyte progenitor cells (pink-orange). The hydrophobic poly(cyclohexyl methacrylate) (pCHMA) thin-film substrate permits the natural segregation of glial cell subtypes with dissimilar adhesion properties.