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Copper-Catalyzed Acylhalogenation of 3-Methylanthranils with Acid Halides: Synthesis of N-(2-(2-Haloyl)phenyl)amides

Baihui Liang,Tingting Wen, Guanrui Chen,Zechun Cai,Jucai Xu,Xiuwen Chen,Zhongzhi Zhu

Advanced Synthesis & Catalysis（2022）

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Abstract
A copper-catalyzed acylhalogenation reaction of 3-methylanthranils with acid halides, which utilizes the acyl halide as both the acylating and halogenating source, is described. This process involves N-O/C-H/C-X bond cleavages and C-N/C-X bond formations to furnish N-(2-(2-haloyl)phenyl)amides. Furthermore, this difunctional conversion using the N-O bond and oxygen as oxidants displays good tolerance for different functional groups.
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Key words
Acylhalogenation,3-methylanthranils,acid halides,N-O bond as oxidants
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