Micro-hydrogel injectables that deliver effective CAR-T immunotherapy against 3D solid tumor spheroids

Anisha B. Suraiya,Vera J. Evtimov,Vinh X. Truong,Richard L. Boyd,John S. Forsythe,Nicholas R. Boyd

Translational Oncology（2022）

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摘要

•CAR-T cells are encapsulated in injectable, gelatin-based microgels.•Encapsulated CAR-T cells possessed high viability and retained T cell phenotype.•CAR-T cells displayed potent on-target cytotoxicity to 3D solid tumor spheroids.

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关键词

Microgels,Cell encapsulation,Immunotherapy,CAR-T cells,Cell delivery,Tumor spheroids

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