Quantitative Analysis of Sympathetic and Nociceptive Innervation Across Bone Marrow Regions in Mice

Shinya Fujita,Takayuki Morikawa,Shinpei Tamaki,Maiko Sezaki,Hitoshi Takizawa,Shinichiro Okamoto,Keisuke Kataoka,Keiyo Takubo

Experimental Hematology（2022）

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摘要

•Innervation in various bones, the BM, and the spleen was mapped and characterized.•The site of nerve entry into the BM was clarified for each bone.•Sympathetic and nociceptive nerves mostly run parallel with arteries in the BM.•Nociceptive nerves mainly supply CGRP in the BM to regulate HSPC mobilization.•Nociceptive nerves in the BM are sensitive to neurotoxic chemotherapeutic agents.

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关键词

bone marrow,innervation,nociceptive,sympathetic

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