Molecular Analysis of pSK1 par: A Novel Plasmid Partitioning System Encoded by Staphylococcal Multiresistance Plasmids

Helena Y Chan,Slade O Jensen,Rebecca J LeBard,William A Figgett, Evelyn Lai,Alice E Simpson,Anthony J Brzoska,Danielle S Davies,Angela M Connolly,Stuart J Cordwell,Brady A Travis,Raul Salinas,Ronald A Skurray,Neville Firth,Maria A Schumacher

Journal of Molecular Biology（2022）

引用 4|浏览9

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摘要

•The prototypical multiresistance plasmid pSK1 encodes a single par protein, pSK1 Par.•Unlike typical par systems, requiring 2 proteins, pSK1 Par alone drives pSK1 partition.•pSK1 Par-DNA structure reveals distinct CBP fold and centromere binding mechanism.•Biochemical analyses show pSK1 Par forms extended coiled-coiled oligomer.•In vivo data show pSK1 Par enhances plasmid separation of plasmids from clusters.

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关键词

pSK1 plasmid,DNA segregation,par protein,X-ray crystallography,S. aureus

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