A molecular dyad delivered by biodegradable polymeric nanoparticles for combined PDT and NO-PDT in cancer cells

Cristina Parisi,Giuseppe Longobardi,Adriana C E Graziano,Aurore Fraix,Claudia Conte,Fabiana Quaglia,Salvatore Sortino

Bioorganic Chemistry（2022）

引用 5|浏览10

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摘要

•1O2 and NO are photogenerated in high yields with an NO fluorescent reporter.•The dyad is entrapped in polymeric nanoparticles and delivered into cancer cells.•The formulation induces cancer cells mortality at very low light doses.

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关键词

Photodynamic therapy,Nitric oxide,Light,Multimodal therapy,Polymer nanoparticles

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