SUMOylation inhibition overcomes proteasome inhibitor resistance in multiple myeloma

Guus J. J. E. Heynen,Francis Baumgartner,Michael Heider,Upayan Patra, Maximilian Holz,Jan Braune, Melanie Kaiser,Isabell Schäffer,Stefanos A. Bamopoulos,Evelyn Ramberger,Arunima Murgai,Yuen Lam Dora Ng,Uta Margareta Demel,Dominik Laue,Sven Liebig,Josefine Krüger,Martin Janz,Axel Nogai,Markus Schick,Philipp Mertins

Blood advances（2023）

引用 3|浏览49

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摘要

•The SUMO pathway is activated in MM and its magnitude associated with progression and treatment resistance.•SUMO inhibition overcomes proteasome inhibitor resistance by blocking myeloma stress resilience, irrespective of p53 state.

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关键词

proteasome inhibitor resistance,multiple myeloma

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