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Curcumin Loaded Polycaprolactone Scaffold Capable of Anti-Inflammation to Enhance Tracheal Cartilage Regeneration

Minglei Yang,Weiyan Sun,Long Wang,Hai Tang,Xiang Xu,Liangwei Yang,Junjun Ni, Kuoen Zheng,Xu Jiang, Weiwen Xu,Yunlang She,Lei Zhang,Guofang Zhao,Chang Chen

SSRN Electronic Journal（2022）

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Abstract
•Cur/PCL scaffold exhibited a favorable anti-inflammation property in vitro.•Cur/PCL displayed enhanced stability of cartilaginous phenotype in vivo.•Cur/PCL displayed inflammatory-related response in vivo.•Cur/PCL inhibited granulation hyperplasia after orthotopic tracheal transplantation.•Cur/PCL promote rabbit survive after orthotopic tracheal transplantation.
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Key words
Curcumin,Anti-inflammation,Tracheal cartilage regeneration,Drug loading,Tissue engineering
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