Effect of epicatechin on inflammatory cytokines and MAPK/NF-B signaling pathway in lipopolysaccharide-induced acute lung injury of BALB/c mice
GENERAL PHYSIOLOGY AND BIOPHYSICS(2022)
摘要
This study evaluated the anti-inflammatory effect of epicatechin (EC) on acute lung injury (ALI) induced by lipopolysaccharide (LPS) of tracheal installation in BALB/c mice. It was observed that EC could alleviate not only the histopathological changes but also decrease the wet/dry weight (W/D) ratio of lung tissues. It also suppressed the release of IL-1 beta, IL-6, and TNF-alpha in serum, bronchoalveolar lavage fluid (BALF), and lung tissues, respectively. A quantitative real-time PCR-based study further indicated that EC also inhibited the levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) mRNA in lung tissues. In addition, the Western blot report suggested that EC was closely involved in the inhibition of phosphorylation of ERK, JNK, p38, p65, and I kappa B in mitogen-activated protein kinases (MAPK) and nuclear factor-kappa B (NF-kappa B) signaling pathway. These results provide an experimental and theoretical basis for treating pulmonary inflammation by EC.
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关键词
(-)-Epicatechin,Acute lung injury,Inflammation,Phosphorylation
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