Study on the clinical correlation between serum total IgE level and peripheral blood eosinophil count in patients with eczema

Objective:To explore the correlation between the expression of serum total IgE level and peripheral blood EOS count in patients with eczema and the severity of clinical eczema.Methods:The EASI and pruritus VAS score were used to evaluate the disease severity of 100 patients with eczema.According to the EASI score,patients with eczema were divided into three groups:mild(<7 points)、moderate(7-15 points)and severe(>15 points).At the same time,the serum total IgE level and peripheral blood EOS count were tested before and after the 4-week Chinese medicine treatment.Results:The serum total IgE level of 42％of eczema patients increased,and the peripheral blood EOS count increased in 26％.In the three groups of mild,moderate,and severe,as the severity of eczema increased,the level of serum total IgE and peripheral blood EOS count continued to increase,and the positive rate increased significantly(all P<0.05).In terms of correlation analysis,the study showed that in patients with eczema total IgE level and EASI score(r=0.421,P<0.01),EOS count and EASI score(r=0.326,P<0.01),EOS count and pruritus VAS score(r=0.529,P<0.01)all show relatively weak positive correlation;and a high proportion of patients had the same changes in IgE and EOS after treatment(82％of IgE is consistent with EASI,76％of EOS is consistent with EASI).Conclusion:This study shows that the total IgE level and EOS count of patients with eczema are positively correlated with the severity of eczema,but at the same time this correlation is relatively limited.In clinical practice,it is necessary to combine the dynamic changes of the individual's own indicators in order to diagnose,comprehensively treat and evaluate eczema.Provide greater reference value in other aspects.