Blockade of IL-6 inhibits tumor immune evasion and improves anti–PD-1 immunotherapy

Wenyi Li,Zhaokun Wu,Weidong Meng,Chaoting Zhang,Mingzhen Cheng,Yuehong Chen,Yini Zou,Kejun Li,Simin Lin,Wenjun Xiong,Ying Wang,Yixiong Lin,Wenhui Ma,Weijie Zhou

Cytokine（2022）

引用 7|浏览6

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摘要

•IL-6-/- mice are less susceptible to develop tumors, compared to WT mice.•Infiltrated CD8+ T cells are found to exhibit high expression in tumor of IL-6-/- mice.•IL-6 acts as a negative regulator in IFNγ-STAT1-MHC-I signaling.•Blockade of IL-6 also increased CD8+ T cells in the CT26 subcutaneous tumors and sensitize animals to anti-PD-1 therapy.

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关键词

Colorectal cancer (CRC),IL-6,Immune evasion,MHC-I molecules,Anti-PD-1

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