Association of Gene Polymorphisms DRD3 rs6280, COMT rs4680, and HTR2A rs7322347 with Schizophrenia

Objectives . To seek associations of the genetic polymorphisms rs6280 of the DRD3 gene, rs4680 of the COMT gene, and rs7322347 of the HTR2A gene with schizophrenia. Materials and methods . The cohort included 300 inpatients with paranoid schizophrenia. The healthy control group consisted of 290 subjects. Associations between polymorphisms and study groups were assessed by logistic regression. Results . The severity of positive symptoms on the PANSS in the patient cohort was 14.0 [11.0; 18.0] points, the severity of negative symptoms was 21.0 [17.0; 27.0] points, and severity of other symptoms was 33.0 [27.8; 38.0] points. A between-group difference ( p = 0.012) was found on comparison of the genotype for the rs7322347 polymorphism. The CC genotype of the rs6280 polymorphism was found to be associated with schizophrenia (OR 3.37 (1.50; 8.03)). The TT genotype of the rs7322347 polymorphism was associated with the control group (OR 1.83 (1.25; 2.68)). Conclusions . The analysis results confirmed the hypothesis that the genetic polymorphisms rs7322347 of the HTR2A gene ( p = 0.006) and rs6280 of the DRD3 gene ( p = 0.004) are associated with the disease. The hypothesis that there is a link between the rs4680 polymorphism of the COMT gene could not be confirmed.