Protective immunity of plant-produced African horse sickness virus serotype 5 chimaeric virus-like particles (VLPs) and viral protein 2 (VP2) vaccines in IFNAR-/- mice

Martha M O'Kennedy,Peter Coetzee,Otto Koekemoer,Lissinda du Plessis,Carina W Lourens,Lusisizwe Kwezi,Ilse du Preez,Sipho Mamputha,Nobalanda B Mokoena,Daria A Rutkowska,Jan A Verschoor,Yolandy Lemmer

Vaccine（2022）

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摘要

•Plant produced AHSV serotype 5 VLPs and VP2 vaccines compared in IFNAR-/- mice.•Adjuvanted AHSV-5 VLPs and VP2 resulting in high titres of neutralizing antibodies.•Protective immunity of monovalent African horse sickness VLP and VP2 vaccines in IFNAR-/- mice.•Plant produced AHSV-5 VP2 suitable as vaccine candidate and in serological assays.•Promising new generation African horse sickness vaccine candidates.

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关键词

Plant-produced,Orbivirus,African horse sickness virus (AHSV),Chimaeric virus-like particles (VLPs),Soluble viral protein 2 (VP2)

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