Age and sex related differences in orthostatic cerebral oxygenation: Findings from 2764 older adults in the Irish Longitudinal Study on Ageing (TILDA)

•We profiled the cerebral oxygenation response to orthostasis in large well-described community-dwelling population, adjusting for a large number of confounders.•Older age groups had a larger initial drop in cerebral oxygenation and impaired stabilization.•Women experienced a smaller drop in oxygenation compared to men, but impaired stabilization was more marked in women.•Those treated with anti-hypertensive medications had deficits in recovery of cerebral oxygenation after standing.•Hypoperfusion did not correlate with reported orthostatic symptoms.