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Combined Blockade Of PD-1 and TIGIT is not Sufficient to Improve the Function Of CD8+ T-Cells in Chronic Lymphocytic Leukemia.

Fatemeh Hatefi,Hossein Asgarian-Omran,Hadi Hossein-Nataj,Armin Akbar,Ramin Shekarriz,Ehsan Zaboli,Ghasem Janbabai,Mohsen Tehrani

Asian Pacific journal of cancer prevention : APJCP（2022）

Cited 2|Views4
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Abstract
Collectively, combined blockade of PD-1 and TIGIT failed to restore the proliferation and function of CD8+ T-cells isolated from CLL patients.
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Key words
Chronic Lymphocytic Leukemia,PD-1,T-cell exhaustion,TIGIT,immune checkpoint blockade
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