Population pharmacokinetic modelling of febuxostat in healthy subjects and people with gout.

Bishoy Kamel,Ahmad Y Abuhelwa,David Foster,Janna K Duong,Garry G Graham,Kenneth M Williams,Kevin D Pile,Richard O Day

British journal of clinical pharmacology（2022）

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摘要

Renal function and body mass index were significant covariates. Further work is warranted to investigate the clinical relevance of these results, notably as renal impairment and obesity are common occurrences in people with gout.

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clinical pharmacology,febuxostat,gout,hyperuricaemia,population pharmacokinetics,rheumatology

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