Complementary Nck1/2 Signaling in Podocytes Controls α Actinin-4-Mediated Actin Organization, Adhesion, and Basement Membrane Composition.

Claire E Martin,Noah J Phippen,Ava Keyvani Chahi,Manali Tilak,Sara L Banerjee,Peihua Lu,Laura A New,Casey R Williamson,Mathew J Platt,Jeremy A Simpson,Mira Krendel,Nicolas Bisson,Anne-Claude Gingras,Nina Jones

Journal of the American Society of Nephrology : JASN（2022）

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摘要

These findings reveal distinct, yet complementary, roles for Nck proteins in regulating podocyte adhesion, controlling GBM composition, and sustaining filtration barrier integrity.

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关键词

Nck1/2,actin cytoskeleton,basement membrane,cell adhesion,extracellular matrix,mass spectrometry,mouse models,podocyte,proteomics,transcriptomics

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