Reduced Cathepsin L expression and secretion into the extracellular milieu contribute to lung fibrosis in systemic sclerosis.

Joe E Mouawad,Shailza Sharma,Ludivine Renaud,Joseph M Pilewski,Satish N Nadig,Carol Feghali-Bostwick

Rheumatology (Oxford, England)（2023）

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摘要

Our findings identify CTSL as a protein protective against lung fibrosis via its activation of antifibrotic ES, and whose expression in SSc pLFs and lung tissues is suppressed. Identifying strategies to boost CTSL endogenous levels in SSc patients could serve as a viable therapeutic strategy.

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Cathepsin L,SSc,TGF-β,endostatin,extracellular vesicles,fibroblasts,fibrosis,lung,scleroderma

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