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Curcumin regulates anti-inflammatory responses by AXL/JAK2/STAT3 signaling pathway in experimental autoimmune encephalomyelitis

Mengjiao Sun,Ning Liu,Jing Sun,Xiaoling Li,Hongxia Wang,Wenjing Zhang,Qinfang Xie,Manxia Wang

Neuroscience Letters（2022）

Cited 9|Views3
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Abstract
•Curcumin can alleviate the symptom of EAE mice.•Curcumin attenuates inflammatory response by inactivating the AXL/JAK2/STAT3 signaling pathway.•AXL/GAS6 can be a potential therapeutic or regulatory target for MS.•Curcumin can be used for the clinical management of MS.
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Key words
Multiple sclerosis,Experimental autoimmune encephalomyelitis,Microglia,Curcumin
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