Interleukin-18 promotes fibroblast senescence in pulmonary fibrosis through down-regulating Klotho expression.

Li-Ming Zhang,Jun Zhang,Ying Zhang,Chang Fei,Lin Wang,Zong-Wei Yi,Zai-Qi Zhang

Biomedicine & Pharmacotherapy（2019）

引用 45|浏览9

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摘要

•IL-18 induces primary lung fibroblast senescence by down-regulating Klotho expression.•Overexpression of Klotho protects lung fibroblast against senescence induced by IL-18.•Neutralization of IL-18 by IL-18BP ameliorates lung fibroblast senescence in bleomycin-induced pulmonary fibrosis mice.

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关键词

Pulmonary fibrosis,IL-18,IL-18 binding protein,Fibroblasts,Klotho

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