Complete Resolution of Paraneoplastic Syndrome of Inappropriate Antidiuretic Hormone Secretion Following Thymic Small Cell Carcinoma Thoracoscopic Resection

Abstract Thymic neuroendocrine tumors (TNET) are rare anterior mediastinal neoplasms often associated with paraneoplastic syndromes. A patient presented with intractable hyponatremia and a Dotatate-avid mediastinal mass. Following medical optimization, she underwent thoracoscopic thymectomy with en-bloc thymic small cell carcinoma resection. Her symptoms resolved and sodium levels normalized. In localized disease, curative-intent, minimally invasive TNET resection is safe and effective following preoperative staging and paraneoplastic syndrome management.