Determinants of antibody response to severe acute respiratory syndrome coronavirus 2 mRNA vaccines in people with HIV

Frédérique Chammartin,Katharina Kusejko,Chloé Pasin,Alexandra Trkola,Matthias Briel,Patrizia Amico, Marcel P Stoekle,Anna L Eichenberger,Barbara Hasse,Dominique L Braun,Macé M Schuurmans,Thomas F Müller, Michael Tamm,Nicolas J Mueller,Andri Rauch,Michael T Koller,Huldrych F Günthard,Heiner C Bucher,Benjamin Speich,Irene A Abela

AIDS（2022）

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摘要

We identified determinants of SARS-CoV-2 mRNA vaccine antibody response in people with HIV (PWH). Antibody response was higher among PWH less than 60 years, with CD4(+) cell count superior to 350 cells/mu l and vaccinated with mRNA-1273 by Moderna compared with BNT162b2 by Pfizer-BioNTech. Preinfection with SARS-CoV-2 boosted the antibody response and smokers had an overall lower antibody response. Elderly PWH and those with low CD4(+) cell count should be prioritized for booster vaccinations.

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