Anti-atopic dermatitis effect of a modified Huang-Lian-Jie-Du decoction and its active fraction on 2,4-dinitrobenzene and MC903-induced mouse models

Lan Wang,Zhen Hu,Wen Yang,Steven King Fan Loo,Siu Po Ip,Yan-Fang Xian,Zhi-Xiu Lin

Phytomedicine（2022）

引用 7|浏览9

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摘要

MHLJDD-F could markedly relieve AD symptoms induced by DNCB and MC903 in mice, at least in part, through improving the epidermal barrier function and inhibiting skin inflammation via suppression of the activation of NF-κB and MAPKs pathways and regulation of the gut microflora dysbiosis.Image, graphical abstract

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关键词

Atopic dermatitis,Modified Huang-Lian-Jie-Du decoction,DNCB-sensitized mouse,MC903-sensitized mouse,NF-κB and MAPK pathways,Gut microbiota

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