New s-Triazine/Tetrazole conjugates as potent antifungal and antibacterial agents: Design, molecular docking and mechanistic study

Ramadan Ahmed Mekheimer,Gamal El-Din A. Abuo-Rahma,Mohamed Abd-Elmonem,Ramadan Yahia,Mohamed Hisham,Alaa M. Hayallah,Sara M. Mostafa,Fatma A. Abo-Elsoud,Kamal Usef Sadek

Journal of Molecular Structure（2022）

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摘要

•New s-Triazine/Tetrazole hybrid molecules have been synthesized via simple and efficient multi-component reaction.•The synthesized scaffolds showed excellent antibacterial activity agains P.aeruginosa and E. colibacterial strain and the most potent compound showed good inhibitory effect for DNA gyrase topoisomerase IV ATPase as well as E.coli TOPO IV.•Molecular docking study was presented to explain numerous key binding interactions.

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关键词

s-Triazine/Tetrazole,Microwave heating,Antifungal,Lanosterol 14-α-demethylase inhibition antibacterial,Molecular Docking

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