Crystal structure of BtrK, a decarboxylase involved in the (S)-4-amino-2-hydroxybutyrate (AHBA) formation during butirosin biosynthesis

Laura A. Rivas Arenas,Fernanda C.R. de Paiva,Nicolas de O． Rossini,YanYan Li,Jonathan Spencer,Peter Leadlay,Marcio V.B. Dias

Journal of Molecular Structure（2022）

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摘要

•Structural characterization of BtrK, a decarboxylase involved in the biosynthesis of butirosin, was performed.•BtrK has a structure similar to diaminopimelic acid decarboxylases (DAPDC), including the essential residues of the active site.•The molecular docking of a truncated version of the substrate indicates a hypothetical binding mode of the glutamate tethered to the Peptidyl Carrier Protein (PCP) BtrI.

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关键词

Aminoglycosides,Butirosin,AHBA,(S)-4-amino-2-hydroxybutyrate,Decarboxylase,PLP-dependent enzymes

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