General Guidelines for Biological Sampling

No AccessJun 2022General Guidelines for Biological SamplingAuthors/Editors: Katherine von Stackelberg, Pamela R. D. Williams, Ernesto Sánchez-TrianaKatherine von StackelbergSearch for more papers by this author, Pamela R. D. WilliamsSearch for more papers by this author, Ernesto Sánchez-TrianaSearch for more papers by this authorhttps://doi.org/10.1596/978-1-4648-1819-6_ch4AboutView ChaptersFull TextPDF (0.5 MB) ToolsAdd to favoritesDownload CitationsTrack Citations ShareFacebookTwitterLinked In Abstract: Provides an overview of biological sampling conducted for each participating individual in order to provide data on both internal-exposure concentrations and potential health outcomes associated with exposures to the contaminants of concern (CoCs). Biological samples help to quantify total exposure to the CoCs at each artisanal small-scale gold mining (ASGM) and reference site and will also help confirm or validate estimates of CoC exposure based on the exposure-factor data and environmental-sampling data collected at each site. Key factors to consider when evaluating potential biomarkers include (1) how well the biomarker correlates with the external exposure to appropriate forms of the contaminant; (2) how well the biomarker correlates with the contaminant concentration in tissue relative to the health outcome; (3) how well the biomarker measurement correlates with changes in the effective dose at the target tissue over time; (4) an understanding of the cultural characteristics of the population; (5) technology availability; and (6) invasiveness of sample collection. Previous chapterNext chapter FiguresreferencesRecommendeddetails View Published: June 2022ISBN: 978-1-4648-1819-6 Copyright & Permissions Related TopicsEnvironmentIndustryLaw and DevelopmentSocial Protections and Labor KeywordsGOLD MININGEXTRACTIVE INDUSTRYMERCURYHOUSEHOLD SURVEYSHEALTH OUTCOMESSURVEILLANCE OF LAND AND SOIL DEGRADATIONSAMPLING STRATEGYLABORATORY ANALYSISENVIRONMENTAL RISK MANAGEMENTHUMAN HEALTH RISKS PDF DownloadLoading ...