Clodronate detection and effects on markers of bone resorption are prolonged following a single administration to horses.

Heather K Knych,Carrie J Finno,Scott Katzman, Declan Ryan,Daniel S McKemie,Philip H Kass,Rick M Arthur

Equine veterinary journal（2022）

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摘要

Based on assessment of protein biomarkers, clodronate appears to influence osteoclasts at label doses. Furthermore, results of this study support racing regulations that preclude horses administered bisphosphonates for medical reasons, from racing for a prolonged period of time.

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关键词

analgesic,bisphosphonate,bone,clodronate,horse,pharmacokinetics

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