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Epstein-Barr Virus Tegument Protein BKRF4 is a Histone Chaperone

Yongrui Liu,Yue Li,Hongyu Bao,Yanhong Liu,Liu Chen,Hongda Huang

Journal of Molecular Biology（2022）

Cited 3|Views19
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Abstract
•Histone chaperones have been only found in eukaryotes.•We identified the EB virus tegument protein BKRF4 as a bona fide histone chaperone.•We revealed the molecular basis of its recognition of histones H3–H4 and H2A–H2B.•The conserved BKRF4 motifs D/EL and DEF/Y/W target H3–H4 and H2A–H2B, respectively.
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Key words
Histone chaperone,BKRF4,Crystal structure,Epstein-Barr virus tegument protein
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