Ligand-Promoted Fluorinated Olefination of Isatins at the C5 Position via a Palladium Catalyst
Organic Letters(2022)
摘要
A palladium-catalyzed nondirected fluorinated olefination was developed. The oxalyl amide ligand greatly improved the yield of the reaction. A wide variety of isatin derivatives were well tolerated and yielded the corresponding products in moderate to good yields. Various fluorinated olefins were also compatible. The application and synthesis of bioactive compounds such as a Metisazone derivative highlight the synthetic value of this approach.
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关键词
fluorinated olefination,isatins,catalyst,palladium,ligand-promoted
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