Comprehensive study of pydiflumetofen in Danio rerio: Enantioselective insight into the toxic mechanism and fate
Environment International(2022)
摘要
•The toxic effects of R-PYD against zebrafish was higher than S-enantiomer.•Stronger binding of R with SDH causing lower enzyme activity led to higher toxicity.•Enantioselectivity of uptake, distribution and metabolism of PYD was observed.•The phase I and phase II metabolic pathways of PYD in zebrafish were first proposed.•Several highly toxic metabolites need to be given more attention in the future.
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关键词
Pydiflumetofen,Enantioselective toxicity,Toxic mechanism,Metabolic pathway,Ecological risk
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