Integrated analysis using ToppMiR uncovers altered miRNA- mRNA regulatory networks in pediatric hepatocellular carcinoma-A pilot study.

Senyo S Whyte,Rebekah Karns,Kyung-Won Min,Jung-Hyun Cho,Sanghoon Lee,Charissa Lake,Alexander Bondoc,Je-Hyun Yoon,Soona Shin

Cancer reports (Hoboken, N.J.)（2023）

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摘要

Our pilot study indicates that alterations in miRNA-mRNA networks were detected in not only tumor tissues but also corresponding non-tumorous liver tissues from patients with pediatric HCC, suggesting multi-faceted roles of miRNAs in disease progression. Our results may lead to novel hypotheses for future large-scale studies.

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关键词

RNA sequencing,ToppMiR,miRNA,pediatric hepatocellular carcinoma

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